Home' South Florida Gay News : SFGN 120215 Contents 22 • 12.2.2015
(darunavir and cobicistat)
Please read this information before you start taking PREZCOBIX and each time
you get a refill. There may be new information. This information does not take
the place of talking with your healthcare provider about your medical condition
What is the most important information I should know about PREZCOBIX?
• PREZCOBIX may cause liver problems. Some people taking PREZCOBIX may
develop liver problems which may be life-threatening. Your healthcare provider
should do blood tests before and during your treatment with PREZCOBIX. If
you have chronic hepatitis B or C infection, your healthcare provider should
check your blood tests more often because you have an increased chance of
developing liver problems.
Tell your healthcare provider if you have any of the below signs and symptoms
of liver problems.
• dark (tea colored) urine
• yellowing of your skin or whites of your eyes
• pale colored stools (bowel movements)
• pain or tenderness on your right side below your ribs
• loss of appetite
• PREZCOBIX may cause severe or life-threatening skin reactions or rash.
Sometimes these skin reactions and skin rashes can become severe and
require treatment in a hospital. Call your healthcare provider right away if you
develop a rash. Stop taking PREZCOBIX and call your healthcare provider
right away if you develop any skin changes with symptoms below:
• muscle or joint pain
• blisters or skin lesions
• mouth sores or ulcers
• red or inflamed eyes, like "pink eye" (conjunctivitis)
• PREZCOBIX when taken with certain other medicines can cause new or
worse kidney problems, including kidney failure. Your healthcare provider
should check your kidneys before you start and while you are taking
See "What are the possible side effects of PREZCOBIX?" for more information
about side effects.
What is PREZCOBIX?
PREZCOBIX is a prescription HIV-1 (Human Immunodeficiency Virus 1) medicine
used with other antiretroviral medicines to treat HIV-1 infection in adults. HIV is
the virus that causes AIDS (Acquired Immune Deficiency Syndrome).
PREZCOBIX contains the prescription medicines PREZISTA (darunavir) and
It is not known if PREZCOBIX is safe and effective in children under 18 years
When used with other antiretroviral medicines to treat HIV-1 infection,
PREZCOBIX may help:
• reduce the amount of HIV-1 in your blood. This is called "viral load".
• increase the number of CD4+ (T) cells in your blood that help fight off other
Reducing the amount of HIV-1 and increasing the CD4+ (T) cells in your blood
may help improve your immune system. This may reduce your risk of death
or getting infections that can happen when your immune system is weak
PREZCOBIX does not cure HIV-1 infection or AIDS. You must keep taking HIV-1
medicines to control HIV-1 infection and decrease HIV-related illnesses.
Avoid doing things that can spread HIV-1 infection to others.
• Do not share or re-use needles or other injection equipment.
• Do not share personal items that can have blood or body fluids on them, like
toothbrushes and razor blades.
• Do not have any kind of sex without protection. Always practice safe sex by
using a latex or polyurethane condom to lower the chance of sexual contact
with semen, vaginal secretions, or blood.
Ask your healthcare provider if you have any questions on how to prevent
passing HIV to other people.
Who should not take PREZCOBIX?
Do not take PREZCOBIX with any of the following medicines:
• alfuzosin (Uroxatral®)
• cisapride (Propulside®, Propulsid® Quicksolv)
• colchicine (Colcrys®, Mitigare®), if you have liver or kidney problems
• dronedarone (Multaq®)
• ergot-containing medicines:
• dihydroergotamine (D.H.E. 45®, Embolex®, Migranal®)
• ergotamine tartrate (Cafergot®, Ergomar®, Ergostat®, Medihaler®,
Migergot®, Wigraine®, Wigrettes®)
• methylergonovine (Methergine®)
• lovastatin or a product that contains lovastatin (Altoprev®, Advicor®,
• lurasidone (Latuda®)
• midazolam (Versed®), when taken by mouth
• pimozide (Orap®)
• ranolazine (Ranexa®)
• rifampin (Rifadin®, Rifater®, Rifamate®, Rimactane®)
• sildenafil (Revatio®), when used for the treatment of pulmonary arterial
• simvastatin or a product that contains simvastatin (Simcor®, Vytorin®, Zocor®)
• St. John's Wort (Hypericum perforatum), or a product that contains
St. John's Wort
• triazolam (Halcion®)
Serious problems can happen if you take any of these medicines with
What should I tell my healthcare provider before taking PREZCOBIX?
Before taking PREZCOBIX, tell your healthcare provider if you:
• have liver problems, including hepatitis B or hepatitis C
• have kidney problems
• are allergic to sulfa (sulfonamide)
• have diabetes
• have hemophilia
• have any other medical condition
• are pregnant or plan to become pregnant. It is not known if PREZCOBIX will
harm your unborn baby. Tell your healthcare provider if you become pregnant
while taking PREZCOBIX.
IMPORTANT PATIENT INFORMATION
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