Home' South Florida Gay News : SFGN 061715 Contents 14 // 6.17.2015 // SFGN.com // soflagaynews // SouthFloridaGayNews
ATRIPLA® (efavirenz/emtricitabine/tenofovir disoproxil fumarate)
Other possible side effects with ATRIPLA:
• Changes in body fat. Changes in body fat develop in some patients taking
anti HIV-1 medicine. These changes may include an increased amount of fat
in the upper back and neck ("buffalo hump"), in the breasts, and around the
trunk. Loss of fat from the legs, arms, and face may also happen. The cause
and long-term health effects of these fat changes are not known.
• Skin discoloration (small spots or freckles) may also happen with ATRIPLA.
• In some patients with advanced HIV infection (AIDS), signs and symptoms
of in ammation from previous infections may occur soon after anti-HIV
treatment is started. It is believed that these symptoms are due to an
improvement in the body's immune response, enabling the body to ght
infections that may have been present with no obvious symptoms. If you
notice any symptoms of infection, please inform your doctor immediately.
• Additional side effects are in ammation of the pancreas, allergic reaction
(including swelling of the face, lips, tongue, or throat), shortness of breath,
pain, stomach pain, weakness and indigestion.
Tell your healthcare provider or pharmacist if you notice any side effects while
Contact your healthcare provider before stopping ATRIPLA because of side effects
or for any other reason.
This is not a complete list of side effects possible with ATRIPLA. Ask your healthcare
provider or pharmacist for a more complete list of side effects of ATRIPLA and all
the medicines you will take.
How do I store ATRIPLA?
• Keep ATRIPLA and all other medicines out of reach of children.
• Store ATRIPLA at room temperature 77°F (25°C).
• Keep ATRIPLA in its original container and keep the container tightly closed.
• Do not keep medicine that is out of date or that you no longer need. If you
throw any medicines away make sure that children will not nd them.
General information about ATRIPLA:
Medicines are sometimes prescribed for conditions that are not mentioned in
patient information lea ets. Do not use ATRIPLA for a condition for which it was
not prescribed. Do not give ATRIPLA to other people, even if they have the same
symptoms you have. It may harm them.
This lea et summarizes the most important information about ATRIPLA. If you
would like more information, talk with your healthcare provider. You can ask your
healthcare provider or pharmacist for information about ATRIPLA that is written for
Do not use ATRIPLA if the seal over bottle opening is broken or missing.
What are the ingredients of ATRIPLA?
Active Ingredients: efavirenz, emtricitabine, and tenofovir disoproxil fumarate
Inactive Ingredients: croscarmellose sodium, hydroxypropyl cellulose,
microcrystalline cellulose, magnesium stearate, sodium lauryl sulfate. The lm
coating contains black iron oxide, polyethylene glycol, polyvinyl alcohol, red iron
oxide, talc, and titanium dioxide.
Revised: January 2015
ATRIPLA is a trademark of Bristol-Myers Squibb & Gilead Sciences, LLC.
COMPLERA, EMTRIVA, HEPSERA, STRIBILD, TRUVADA, and VIREAD are trademarks
of Gilead Sciences, Inc., or its related companies. SUSTIVA is a trademark of
Bristol-Myers Squibb Pharma Company. Reyataz and Videx are trademarks of
Bristol-Myers Squibb Company. Pravachol is a trademark of ER Squibb & Sons, LLC.
Other brands listed are the trademarks of their respective owners.
ATRIPLA® (efavirenz/emtricitabine/tenofovir disoproxil fumarate)
• Avoid doing things that can spread HIV-1 to others.
• Do not share needles or other injection equipment.
• Do not share personal items that can have blood or body uids on
them, like toothbrushes and razor blades.
• Do not have any kind of sex without protection. Always practice
safe sex by using a latex or polyurethane condom to lower the chance
of sexual contact with semen, vaginal secretions, or blood.
What are the possible side effects of ATRIPLA?
ATRIPLA may cause the following serious side effects:
• Lactic acidosis (buildup of an acid in the blood). Lactic acidosis can be a
medical emergency and may need to be treated in the hospital. Call your
healthcare provider right away if you get signs of lactic acidosis. (See
"What is the most important information I should know about ATRIPLA?")
• Serious liver problems (hepatotoxicity), with liver enlargement
(hepatomegaly) and fat in the liver (steatosis). Call your healthcare provider
right away if you get any signs of liver problems. (See "What is the most
important information I should know about ATRIPLA?")
"Flare-ups" of hepatitis B virus (HBV) infection, in which the disease
suddenly returns in a worse way than before, can occur if you have HBV and
you stop taking ATRIPLA. Your healthcare provider will monitor your condition
for several months after stopping ATRIPLA if you have both HIV-1 and HBV
infection and may recommend treatment for your HBV. ATRIPLA is not
approved for the treatment of hepatitis B virus infection. If you have advanced
liver disease and stop treatment with ATRIPLA, the " are-up" of hepatitis B
may cause your liver function to decline.
• Serious psychiatric problems. A small number of patients may experience
severe depression, strange thoughts, or angry behavior while taking ATRIPLA.
Some patients have thoughts of suicide and a few have actually committed
suicide. These problems may occur more often in patients who have had
mental illness. Contact your healthcare provider right away if you think you
are having these psychiatric symptoms, so your healthcare provider can
decide if you should continue to take ATRIPLA.
• Kidney problems (including decline or failure of kidney function). If you have
had kidney problems in the past or take other medicines that can cause
kidney problems, your healthcare provider should do regular blood tests
to check your kidneys. Symptoms that may be related to kidney problems
include a high volume of urine, thirst, muscle pain, and muscle weakness.
• Other serious liver problems. Some patients have experienced serious liver
problems including liver failure resulting in transplantation or death. Most of
these serious side effects occurred in patients with a chronic liver disease
such as hepatitis infection, but there have also been a few reports in patients
without any existing liver disease.
• Changes in bone mineral density (thinning bones). Laboratory tests show
changes in the bones of patients treated with tenofovir DF, a component of
ATRIPLA. Some HIV patients treated with tenofovir DF developed thinning of
the bones (osteopenia) which could lead to fractures. If you have had bone
problems in the past, your healthcare provider may need to do tests to check
your bone mineral density or may prescribe medicines to help your bone
mineral density. Additionally, bone pain and softening of the bone (which may
contribute to fractures) may occur as a consequence of kidney problems.
Common side effects:
Patients may have dizziness, headache, trouble sleeping, drowsiness, trouble
concentrating, and/or unusual dreams during treatment with ATRIPLA. These side
effects may be reduced if you take ATRIPLA at bedtime on an empty stomach. They
also tend to go away after you have taken the medicine for a few weeks. If you have
these common side effects, such as dizziness, it does not mean that you will also
have serious psychiatric problems, such as severe depression, strange thoughts, or
angry behavior. Tell your healthcare provider right away if any of these side effects
continue or if they bother you. It is possible that these symptoms may be more
severe if ATRIPLA is used with alcohol or mood altering (street) drugs.
If you are dizzy, have trouble concentrating, or are drowsy, avoid activities that may
be dangerous, such as driving or operating machinery.
Rash may be common. Rashes usually go away without any change in treatment.
In a small number of patients, rash may be serious. If you develop a rash, call
your healthcare provider right away. Rash may be a serious problem in some
children. Tell your child's healthcare provider right away if you notice rash or any
other side effects while your child is taking ATRIPLA.
Other common side effects include tiredness, upset stomach, vomiting, gas,
Links Archive SFGN 062415 Navigation Previous Page Next Page