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ATRIPLA® (efavirenz/emtricitabine/tenofovir disoproxil fumarate)
(CD4+ cells), allowing your immune system to improve. Lowering the amount of
HIV-1 in the blood lowers the chance of death or infections that happen when your
immune system is weak (opportunistic infections).
Does ATRIPLA cure HIV-1 or AIDS?
ATRIPLA does not cure HIV-1 infection or AIDS and you may continue to
experience illnesses associated with HIV-1 infection, including opportunistic
infections. You should remain under the care of a doctor when using ATRIPLA.
Who should not take ATRIPLA?
Together with your healthcare provider, you need to decide whether ATRIPLA is
right for you.
Do not take ATRIPLA if you are allergic to ATRIPLA or any of its ingredients.
The active ingredients of ATRIPLA are efavirenz, emtricitabine, and tenofovir DF.
See the end of this lea et for a complete list of ingredients.
What should I tell my healthcare provider before taking ATRIPLA?
Tell your healthcare provider if you:
• Are pregnant or planning to become pregnant (see "What should I avoid
while taking ATRIPLA?").
• Are breastfeeding (see "What should I avoid while taking ATRIPLA?").
• Have kidney problems or are undergoing kidney dialysis treatment.
• Have bone problems.
• Have liver problems, including hepatitis B virus infection. Your healthcare
provider may want to do tests to check your liver while you take ATRIPLA or
may switch you to another medicine.
• Have ever had mental illness or are using drugs or alcohol.
• Have ever had seizures or are taking medicine for seizures.
What important information should I know about taking other medicines with
ATRIPLA may change the effect of other medicines, including the ones for
HIV-1, and may cause serious side effects. Your healthcare provider may
change your other medicines or change their doses. Other medicines, including
herbal products, may affect ATRIPLA. For this reason, it is very important to let
all your healthcare providers and pharmacists know what medications, herbal
supplements, or vitamins you are taking.
MEDICINES YOU SHOULD NOT TAKE WITH ATRIPLA
• ATRIPLA also should not be used with Combivir (lamivudine/zidovudine),
COMPLERA®, EMTRIVA, Epivir, Epivir-HBV (lamivudine), Epzicom (abacavir
sulfate/lamivudine), STRIBILD®, Trizivir (abacavir sulfate/lamivudine/
zidovudine), TRUVADA, or VIREAD. ATRIPLA also should not be used with
SUSTIVA unless recommended by your healthcare provider.
• Vfend (voriconazole) should not be taken with ATRIPLA since it may lose its
effect or may increase the chance of having side effects from ATRIPLA.
• ATRIPLA should not be used with HEPSERA® (adefovir dipivoxil).
It is also important to tell your healthcare provider if you are taking any of the
• Fortovase, Invirase (saquinavir), Biaxin (clarithromycin), Noxa l (posaconazole),
Sporanox (itraconazole), or Victrelis (boceprevir); these medicines may need
to be replaced with another medicine when taken with ATRIPLA.
• Calcium channel blockers such as Cardizem or Tiazac (diltiazem), Covera HS
or Isoptin (verapamil) and others; Crixivan (indinavir), Selzentry (maraviroc);
the immunosuppressant medicines cyclosporine (Gengraf, Neoral,
Sandimmune, and others), Prograf (tacrolimus), or Rapamune (sirolimus);
Methadone; Mycobutin (rifabutin); Rifampin; cholesterol-lowering
medicines such as Lipitor (atorvastatin), Pravachol (pravastatin sodium), and
Zocor (simvastatin); or the anti-depressant medications bupropion (Wellbutrin,
Wellbutrin SR, Wellbutrin XL, and Zyban) or Zoloft (sertraline); dose changes
may be needed when these drugs are taken with ATRIPLA.
• Videx, Videx EC (didanosine); tenofovir DF (a component of ATRIPLA) may
increase the amount of didanosine in your blood, which could result in more
side effects. You may need to be monitored more carefully if you are
taking ATRIPLA and didanosine together. Also, the dose of didanosine may
need to be changed.
ATRIPLA® (efavirenz/emtricitabine/tenofovir disoproxil fumarate)
• Reyataz (atazanavir sulfate), Prezista (darunavir) with Norvir (ritonavir), or
Kaletra (lopinavir/ritonavir); these medicines may increase the amount of
tenofovir DF (a component of ATRIPLA) in your blood, which could result in
more side effects. Reyataz is not recommended with ATRIPLA. You may need
to be monitored more carefully if you are taking ATRIPLA, Prezista, and
Norvir together, or if you are taking ATRIPLA and Kaletra together. The dose of
Kaletra should be increased when taken with efavirenz.
• Medicine for seizures [for example, Dilantin (phenytoin),
Tegretol (carbamazepine), or phenobarbital]; your healthcare provider may
want to switch you to another medicine or check drug levels in your blood
from time to time.
These are not all the medicines that may cause problems if you take ATRIPLA.
Be sure to tell your healthcare provider about all medicines that you take.
Keep a complete list of all the prescription and nonprescription medicines as well
as any herbal remedies that you are taking, how much you take, and how often
you take them. Make a new list when medicines or herbal remedies are added
or stopped, or if the dose changes. Give copies of this list to all of your healthcare
providers and pharmacists every time you visit your healthcare provider or ll a
prescription. This will give your healthcare provider a complete picture of the
medicines you use. Then he or she can decide the best approach for your situation.
How should I take ATRIPLA?
• Take the exact amount of ATRIPLA your healthcare provider prescribes.
Never change the dose on your own. Do not stop this medicine unless your
healthcare provider tells you to stop.
• You should take ATRIPLA on an empty stomach.
• Swallow ATRIPLA with water.
• Taking ATRIPLA at bedtime may make some side effects less bothersome.
• Do not miss a dose of ATRIPLA. If you forget to take ATRIPLA, take the missed
dose right away, unless it is almost time for your next dose. Do not double the
next dose. Carry on with your regular dosing schedule. If you need help in
planning the best times to take your medicine, ask your healthcare provider
• If you believe you took more than the prescribed amount of ATRIPLA, contact
your local poison control center or emergency room right away.
• Tell your healthcare provider if you start any new medicine or change how you
take old ones. Your doses may need adjustment.
• When your ATRIPLA supply starts to run low, get more from your healthcare
provider or pharmacy. This is very important because the amount of virus in
your blood may increase if the medicine is stopped for even a short time. The
virus may develop resistance to ATRIPLA and become harder to treat.
• Your healthcare provider may want to do blood tests to check for certain side
effects while you take ATRIPLA.
What should I avoid while taking ATRIPLA?
• Women should not become pregnant while taking ATRIPLA and for
12 weeks after stopping it. Serious birth defects have been seen in the
babies of animals and women treated with efavirenz (a component of
ATRIPLA) during pregnancy. It is not known whether efavirenz caused these
defects. Tell your healthcare provider right away if you are pregnant. Also
talk with your healthcare provider if you want to become pregnant.
• Women should not rely only on hormone-based birth control, such as pills,
injections, or implants, because ATRIPLA may make these contraceptives
ineffective. Women must use a reliable form of barrier contraception, such as
a condom or diaphragm, even if they also use other methods of birth control.
Efavirenz, a component of ATRIPLA, may remain in your blood for a time after
therapy is stopped. Therefore, you should continue to use contraceptive
measures for 12 weeks after you stop taking ATRIPLA.
• Do not breastfeed if you are taking ATRIPLA. Some of the medicines in
ATRIPLA can be passed to your baby in your breast milk. We do not know
whether it could harm your baby. Also, mothers with HIV-1 should not
breastfeed because HIV-1 can be passed to the baby in the breast milk.
Talk with your healthcare provider if you are breastfeeding. You should stop
breastfeeding or may need to use a different medicine.
• Taking ATRIPLA with alcohol or other medicines causing similar side
effects as ATRIPLA, such as drowsiness, may increase those side effects.
• Do not take any other medicines, including prescription and
nonprescription medicines and herbal products, without checking with your
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